USP8 and posterior cortical atrophy: Interestingly, the docetaxel treatment found higher apoptotic cells compared to USP8 silencing in both PCa cell lines, which was significant in PC3 (siUSP8 vs. docetaxel: 12.89 ± 0.5% vs. 15.4 ± 0.4%, P value = 0.003) but not in DU145 (siUSP8 vs. docetaxel: 6.32 ± 0.44% vs. 7.29 ± 0.59%, P value = 0.2).