Therefore, both the USP8 overexpression and docetaxel treatment were individually found to enhance NF-κB activation, where their combination treatment found the highest level of EGFR, PI3K, IKKα, phosphorylated IκBα and p65, and p65 and the lowest IκBα and thereby severely enhancing NF-κB activation in PCa cells (Figures 4C, D). This evidence concerns the gene CHUK and posterior cortical atrophy.