Therefore, we performed an in vitro study on DU145 and PC3 cell lines and observed the PCa cell’s growth, migration, apoptosis, and expression of EGFR, PI3K, and NF-kB-related proteins upon silencing or overexpressing USP8 followed by with or without docetaxel treatment. The gene discussed is NFKB1; the disease is posterior cortical atrophy.