The elevated EGFR, PI3K/Akt, and NF-kB activation was also previously reported to develop chemoresistance/drug resistance in numerous cancers (11, 22–24), whereas EGFR, PI3K/Akt, and NF-kB were previously reported to be regulated by ubiquitination and deubiquitination (25–28). This evidence concerns the gene AKT1 and cancer.