AKT1 and posterior cortical atrophy: In docetaxel-resistant PCa cells, the chemoresistant action of EGFR is activated by ABCB1 expression via an Akt-dependent route (11), and it was also suggested that the activated PI3K/Akt pathway-mediated upregulation of multidrug resistance protein-1 (MRP-1; ABCC1) might promote the formation of chemoresistant cells in progressive PCa (23).