We found SLC25A25-AS1-related AC020558.2, ZNF32-AS2, AP4B1-AS1, AL355488.1, AC109460.3, SNHG1, C3orf35, LMNTD2-AS1, and AL365330.1 overexpression levels were associated with a short OS, and PFI, and exhibited significant value in diagnosing 1-, 3-, and 5-year suvival time in PC patients. The gene discussed is LMNTD2; the disease is pachyonychia congenita.