SLC25A25-AS1 overexpression was significantly relevant to the infiltration of CD8 T cells, iDCs, macrophages, etc. Besides, AC020558.2, ZNF32-AS2, AP4B1-AS1, AL355488.1, AC109460.3, SNHG1, C3orf35, LMNTD2-AS1, and AL365330.1 were significantly associated with the OS and PFI in PC patients. The gene discussed is CD8A; the disease is pachyonychia congenita.