In a recent comparison of retinoblastoma tumors to pediatric retina, it has been observed that advanced retinoblastoma have lower expression of glycolytic genes, particularly HK1, and altered expression of Krebs cycle-related genes, suggesting reduced dependence on glycolysis and altered Krebs cycle, together with a preference for fatty acid metabolism when compared to the average of all pediatric retinal cells (81). This evidence concerns the gene HK1 and retinoblastoma.