Although circRNAs belong to non-coding RNAs, recent studies unraveled that circRNAs can be translated into proteins or peptides—for example, circ-FBXW7 encodes a novel 21-kDa protein, called FBXW7-185aa, and the depletion of FBXW7-185aa promotes malignant phenotypes in glioma (81). Here, FBXW7 is linked to central nervous system cancer.