In NSCLC experiments, several substances, such as the HIF-1α inhibitor LW6 (78), chetomin (79), gamma-linolenic acid (80), propofol (81), a novel mycotoxin-derived compound GL331 (82), resveratrol (83), sevoflurane (84), flavanols (85), MiR-199a (86, 87), and connective tissue growth factor (88), possess anticancer properties focusing on cancer cell proliferation and invasion capabilities, by downregulating HIF-1α levels. This evidence concerns the gene HIF1A and non-small cell lung carcinoma.