As an example, SF3B1 mutations are often associated with alternative splicing of solute carrier family 25 member 37 (SLC25A37), a splice variant upregulated in MDS-RS patients with thrombocytosis, which acts as a significant importer of iron in the mitochondria (77) with a vivid role in mitochondrial iron delivery in erythroid cells (78). The gene discussed is SF3B1; the disease is myelodysplastic syndrome.