In a study of familial platelet disease with propensity to myeloid malignancies (FPD/AML), an autosomal dominant syndrome characterized by platelet abnormalities and susceptibility to MDS/AML that is caused by the genetic mutation of RUNX1, the authors identified germline RUNX1 mutations in five families with a history of MDS/AML (269). The gene discussed is RUNX1; the disease is myelodysplastic syndrome.