Mice models have revealed that EZH2 or TET2 deficiency alone is sufficient to induce an MDS/MPN phenotype with lethality, while depletion of both EZH2 and TET2 synergistically induces myelodysplasia and strengthens the progression of both MDS and MDS/MPN (114). Here, TET2 is linked to myelodysplastic syndrome.