Mutations in SRSF2 are frequently concomitantly present with runt-related transcription factor 1 (RUNX1), isocitrate dehydrogenase 2 (IDH2), additional sex combs like 1 (ASXL1), TET2 and (STAG2) mutations, where co-mutation of TET2 and SRSF2 has been found predictive of leukemic transformation in MDS and CMML (63). Here, ASXL1 is linked to myelodysplastic syndrome.