Take an IMPC female patient diagnosed at the age of 60 as an example, married, AJCC stage II, ER positive and PR negative tumor, and treatment with BCS and chemotherapy would score a total point of 145.9, by drawing a downward vertical line or entering the information of the patient online, we could obtain the probabilities of 3- or 5-year survival for this patient were 97.0% and 94.0%, respectively. Here, ESR1 is linked to neoplasm.