Proteins related to the metabolism of melanoma cancer cells mainly include heme oxygenase-1 (HO-1/HMOX1), Cathepsin S, Progranulin, FBXO32, etc. For SCC, they mainly include CDC-like kinase 2 (CLK2), serine/threonine kinase 10 (STK10), aldo-keto reductase family 1 member C3 (AKR1C3), etc. There are also some proteins related to cancer migration, such as intercellular adhesion molecule 1 (ICAM-1), tubulin and vascular cellular adhesion molecule-1 (VCAM-1) in melanoma, transforming growth factor-β (TGFβ), and calmodulin-like 5 (CALML5) in SCC. This evidence concerns the gene AKR1C3 and melanoma.