POLE and neoplasm: As other biomarkers in the category of genomic mutation status, phosphatase and tensin homolog (PTEN) (tumor suppressor), DNA polymerase epsilon catalytic subunit (POLE) (a critical protein involved in DNA proofreading and replication), KRAS-serine/threonine kinase 11 (STK11) (tumor suppressor) co-mutation status have shown promising predictive performance.