RSV also downgraded cell cycle-regulated proteins such as retinoblastoma (Rb), cyclin-dependent kinase 2 (CDK2), CDK4, cyclin E, cyclin D1, and proliferating cell nuclear antigen (PCNA) [41], which inhibits the Akt pathways, causing the death of bladder cancer cell, liver cancer cell, and rats aortic vascular smooth muscle cell. This evidence concerns the gene PCNA and urinary bladder carcinoma.