Similarly, in lung adenocarcinoma, CXCL2 secretion by αSMA+ CAFs increases PD-L1 expression by tumor cells [218] and αSMA+ CXCL5-secreting CAFs are positively correlated to PD-L1 expression by melanoma and colorectal carcinoma tumor cells [217]. The gene discussed is CXCL5; the disease is melanoma.