Of note, among FAPHIGH CAF, the recent single cell analyses revealing the heterogeneity within this population mentioned earlier in this review have also strongly suggested that specific clusters, in particular those characterized by wound-healing signature, ECM accumulation, and TGFβ-signaling, are particularly associated with an immunosuppressive environment, at least in some tumor types [70, 144]. This evidence concerns the gene TGFB1 and neoplasm.