For example, artemisinin inactivates CAFs by the suppression of TGFβ signaling in breast cancer [265] and tranilast (Rizaben), a known suppressor of fibroblast proliferation and TGFβ secretion, has demonstrated a synergistic effect with a DC-based vaccine in C57BL/6 mice bearing syngeneic E-G7 lymphoma, LLC1 Lewis lung cancer or B16F1 melanoma [266]. Here, TGFB1 is linked to melanoma.