Also, in patients with androgen-independent advanced PCa, peripheral blood iNKT cell frequency was reduced [164], and results from in vitro activated iNKT with α-GalCer and autologous-irradiated PBMCs for 3–4 weeks, showed that PCa patients had iNKT with defective IFNγ production, compared to healthy controls, whereas IL-4 secretion was normal [164]. Here, IFNG is linked to posterior cortical atrophy.