CD8A and neoplasm: With the introduction of the concept of immunoscore [5, 6], PCa has been classified as a cold tumor, thus driving the attention in the development of strategies aimed at blocking the infiltration/activation of immunosuppressive cells [such as myeloid-derived suppressor cells (MDSCs), type-2 macrophage (M2)-like/tumor-associated macrophages (TAMs), T regulatory (Treg) cells], favoring the infiltration/activation of anti-tumor immune cells (such as natural killer (NK) cells, CD8+ T cells) [7, 8].