Using prostate cancer cells type 3 (PC-3) cell line, orthotopically injected in non-obese diabetes (NOD)/severe combined immunodeficiency (SCID) mice, it has been showed that both neutrophils and TANs are able to secrete higher amount of MMP-9, compared to macrophages and TAMs [115] and TANs-derived MMP-9 supports metastasis development [115]. This evidence concerns the gene MMP9 and Familial prostate cancer.