The relevance of monocyte/macrophage-NK cell interactions in PCa has been demonstrated in a study showing that M2-like/TAM phenotype in tumor environment limit NK cells cytotoxicity against mCRPC cells, by enhancing the PD-L1 levels and reducing NKG2D ligands production through the IL-6/STAT3 pathway (Figure 2M) [150]. The gene discussed is KLRK1; the disease is neoplasm.