Among them, miR-1, which is highly expressed in the lateral femoral muscle of patients with severe COPD, targets and inhibits the expression of IGF-1, causing a decrease in IGF-1 levels in plasma and muscle and inducing autophagy to occur, thereby reducing the protein synthesis rate and causing a decrease in muscle mass (Sandri, 2008; Coşkun et al., 2009; Elia et al., 2009; Corbo et al., 2014). The gene discussed is IGF1; the disease is chronic obstructive pulmonary disease.