Elevated miR-206 in the plasma of COPD patients has been found to be positively correlated with enhanced p50 (NF-κB p50) of κ-light chain of nuclear factor-activated B cells in the quadriceps muscle of patients with GOLD I and II COPD, leading to skeletal muscle dysfunction in COPD (Donaldson et al., 2013). The gene discussed is NFKB1; the disease is chronic obstructive pulmonary disease.