SOSTDC1 and cancer: Sostdc1 has been widely studied in the development of tooth, bone fracture, cancers, kidney disease, vasculature, and hair follicle formation (Collette et al., 2013; Togo et al., 2016; Xiao et al., 2018; Chicana et al., 2019; Millan et al., 2019; Schupp et al., 2021).