Isorhamnetin inhibited oxidative stress (Skalski et al., 2019), and prevented doxorubicin-induced cardiotoxicity (Sun et al., 2013), and isorhamnetin attenuated atherosclerosis through PI3K/AKT activation and HO-1-induced inhibition of macrophage apoptosis (Luo et al., 2015). The gene discussed is AKT1; the disease is atherosclerosis.