Although both SGLT2 inhibitors and glucagon-like peptide-1 receptor agonists were reported to reduce all-cause mortality, cardiovascular mortality, nonfatal myocardial infarction, and renal failure, SGLT2 inhibitors reduced mortality and hospitalization caused by HF more frequently than glucagon-like peptide-1 receptor agonists.46 This evidence concerns the gene SLC5A2 and kidney failure.