Our previous work showed that ADAMTS-1, versican, and pEGFR were expressed in chronic periapical lesions and this protein interaction may participate in the pathogenesis of granuloma and radicular cysts, through the remodeling of the ECM (versican) by ADAMTS-1, producing bioactive fragments, which could activate EGFR, contributing to the formation, growth, and maintenance of injuries [48]. This evidence concerns the gene VCAN and Granuloma.