VD supplementation can reduce the levels of TNF-α and IL-6, improve the coagulation parameters of disseminated intravascular coagulation, and enhance the induction of cathelicidin and B defensin in animal models of sepsis, thereby restricting the inflammatory attack of sepsis on multiple organs throughout the body, including the adrenal cortex (Olejarova et al., 2019). This evidence concerns the gene TNF and Sepsis.