Taken together, APS can effectively antagonize the pathological damage to the adrenal cortex caused by sepsis, alleviate tissue inflammation, stimulate the expression of adrenal STAR, CYP21, CYP17A1, and other active enzymes that have the effect of promoting the synthesis of cortisol, and increase cortisol levels in the serum. This evidence concerns the gene CYP21A2 and Sepsis.