Recently, Zhang et al. (Zhang et al., 2021a) showed that BMSC-derived exosomes promote CRC cell proliferation and enhances CRC cell migration and invasion through miR-424, while the inhibition of miR-424 and elevation of TGFBR3 repress CRC cell proliferation and induce their apoptosis. The gene discussed is TGFBR3; the disease is colorectal carcinoma.