Chen et al. (Chen et al., 2015) report that paracrine factors from adipose MSCs, such as ZEB2, ZEB1, Twist, Slug, and Snail, enhance the metastatic capacity of colon cancer cells in a contact-dependent mode via the Wntsignalling pathway in a co-culture model of colon cancer cells. Here, TWIST1 is linked to colonic neoplasm.