A study conducted by Guo et al. (Guo et al., 2021) showed that MSC-derived exosomes deliver miR-130b-3p to lung cancer cells and block the NFE2L2/TXNRD1 pathway by inhibiting FOXO3 to achieve the effects of promoting cancer cell proliferation, migration, and invasion while inhibiting cancer cell apoptosis. This evidence concerns the gene FOXO3 and cancer.