INPP4B and acute myeloid leukemia: miR222-3p is highly expressed in BMSC-derived exosomes (Furuta et al., 2016), which is delivered to negatively regulate the IRF2/INPP4B signaling pathway, thus, inhibiting proliferation and promoting apoptosis in acute myeloid leukemia (AML) cells by targeting IRF2 (Zhang et al., 2020).