By constructing an interactive multi-omics correlation network, it was found that ganglioside GM3, Cer(d16:2/22:0), and 3Z,6Z,9Z-Pentacosatriene possibly played a central role in the influence of gut microbiome on serum metabolome in PCOS (Figure 4A). The gene discussed is CBLN1; the disease is polycystic ovary syndrome.