SHBG and polycystic ovary syndrome: Of note, three compounds [GM3, PI(20:0/22:6), and methyltestosterone] had strong correlation with almost all PCOS-related phenotypes, including negatively associated with SHBG, and positively correlated with T, FAI, DHEAS, AMH, and LH/FSH (p < 0.05, Figure 3C).