IFNB1 and infection: In the present study, both IFN-ALPHAOMEGA and IFNB1 were extremely significantly up-regulated (LFCs >5) at three timepoints after YC-2020 infection, which has been detected in some previous RNA-Seqs toward PRRSV-2 infection (Lim et al., 2020; Chaudhari et al., 2021).