In infectious diseases, NOTCH2 is possibly involved in regulating the Epstein–Barr virus latent/lytic status (Giunco et al., 2015), and 4.3% of hepatitis C virus-positive cells diffuse large B-cell lymphoma have NOTCH2 mutations (Arcaini et al., 2015). The gene discussed is NOTCH2; the disease is diffuse large B-cell lymphoma.