When adjusted for clinical variables associated with MACE (age, type 2 diabetes, sex, and acute coronary syndrome), high PAI-1+ PEV levels remained associated with MACE, with an HR of 2.49 (95% CI: 1.46-4.25; P = 0.001), and PAI-1+ PEV was the strongest predictor of MACE compared with the best known clinical variables (Table 2, Model 2). The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.