MYBPC3 and hypertrophic cardiomyopathy: The importance of cMyBP-C is highlighted by the fact that allelic variants in cMyBP-C are highly prevalent in hypertrophic cardiomyopathy and implicated to an extent in dilated cardiomyopathy.27, 28, 29, 30 The phosphorylation of serine residues at 273, 282, and 302 within the m-domain of cMyBP-C are essential for normal cardiac function.26