Furthermore, the differences between the high- and intermediate-responding groups seem more evident for IL-1RA after treatment with LPS or C. albicans, although there is a significant difference between the intermediate- and low-responding groups for the production of IL-1β after C. albicans. Overall, the clusters of high, intermediate, and low responders in T1DM show less distinct differences in the production of cytokines after treatment with S. aureus, yet more pronounced differences in the production of cytokines after treatment with Pam3Cys or C. albicans. Here, IL1R1 is linked to type 1 diabetes mellitus.