In this study, we have summarized the existing evidence that electroacupuncture inhibits NLRP3 inflammasome from different pathways such as ionic flux, mitochondrial dysfunction, the production of reactive oxygen species, and lysosomal damage, to treat different inflammatory-related diseases, including digestive system disease, neurological disease, circulatory system disease, reproductive system disease, rheumatic immune system disease, and other diseases. This evidence concerns the gene NLRP3 and cardiovascular disorder.