GBA1 and Parkinson disease: In addition, the GBA mutations worsen the prognosis of PD (Jesús et al., 2016; Lythe et al., 2017; Iwaki et al., 2019b; Mangone et al., 2020; Petrucci et al., 2020; Straniero et al., 2020; Menozzi and Schapira, 2021; Pal et al., 2022; Dulski et al., forthcoming).