Blood studies showed that higher levels of pro-inflammatory markers were linked with a more severe motor phenotype (IFN-γ, TNF-α, IL-2, and IL-10), faster motor progression (CRP and IL-6), cognitive impairment (IFN-γ, TNF-α, IL-2, and IL-10), and worse sleep quality (CRP). The gene discussed is IL2; the disease is Cognitive impairment.