MAPT and Parkinson disease: While these data indicate the presence of ancestry-specific variants of MAPT, the association with PD risk is less convincing; this is unsurprising given that the GWAS association in European populations spans a ∼1 Mb region, which incorporates numerous genes other than MAPT. There is also limited evidence that the 17q21.31 signal implicates MAPT as the causative gene, but rather recent studies favor KANSL1, CRHR1, or LRRC37A2 as likely candidates contributing to PD risk (Loesch et al., 2021; Yao et al., 2021; Bowles et al., 2022).