In contrast to the variable effect of APOE ε4 observed in African ancestry populations, East-Asian population seems to be the most susceptible to the effect of the ε4 allele on AD risk, with a higher odds ratio compared to European and other non-European populations (ε4/ε4 OR:33.12) (Farrer et al., 1997). Here, APOE is linked to Alzheimer disease.