To our knowledge, there are no reports comparing tau pathology or tau biomarkers between European, African, and Asian ancestry individuals stratified by 17q21.31 haplotype; however, given the lack of the H2 haplotype and increased frequency of tauopathy-associated H1 variants in East Asian populations, it may be expected that there will be a differential contribution of the 17q21.31 locus to neurodegenerative risk and tau biomarkers in this population. The gene discussed is MAPT; the disease is tauopathy.