In contrast, a recent multi-ethnic community study reported higher levels of p-tau-181 and p-tau-217 in plasma associated with the APOE ε4 genotype in White, Hispanic, and Black individuals, but that the accuracy of p-tau in classifying AD diagnosis was improved in Hispanic and Black participants compared to white participants (Brickman et al., 2021). Here, APOE is linked to Alzheimer disease.