What’s more, the prion-like domains (PrLD) of hnRNPA2/B1 are the critical components that drive liquid–liquid phase separation (LLPS) and subsequently contribute stress granule (SG) to the hydrogel phase transition (Lee et al., 2016), while the latter is the key mechanism of conversion from neurodegeneration to dementia in the elderly (Lu et al., 2020; Rossi et al., 2020). The gene discussed is HNRNPA2B1; the disease is dementia.