Excepting that HF-O mice tended to have higher TNFα production (215.5 ± 58.9 pg/mL) from Con A-stimulated splenic lymphocytes (p = 0.09) compared to LF mice (199.7 ± 42.1 pg/mL), no significant difference was found in ex vivo production of other cytokines (IL2, IL-4, and TNFα) among the three groups (Supplementary Figure 3). This evidence concerns the gene IL4 and hydrops fetalis.