And oral SVP strongly reduced the T2DM-induced abnormally elevated levels of FBG, GSP, OGTT, AUC of OGTT, HOMA-IRI, and markedly increased the levels of BW, GLP-1, HOMA-ISI in mice, indicating that SVP treatment could ameliorate the hyperglycemic state of T2DM. Here, GLP1R is linked to type 2 diabetes mellitus.