SLC22A12 and hyperuricemia: Animal experiments showed that betaine (5–40 mg/kg), nuciferine (5–40 mg/kg), berberine (6.25–25.0 mg/kg) and dihydroberberine (25–50 mg/kg) could inhibit URAT1 expression and promote the excretion of uric acid in potassium oxonate-induced hyperuricemia mice [68–71].