SLC22A12 and hyperuricemia: Studies have shown that osthol (IC50 = 78.8 μM/l) could non-competitively inhibit URAT1 activity in vitro, and both fraxetin and fraxin (20–40 mg/kg) could negatively regulate URAT1 expression in potassium oxonate-induced hyperuricemia mice [60, 61].