MBP and demyelinating disease: Autoantibodies against alpha-synuclein (a-SYN), a neuronal protein, were found in patients with neurodegenerative conditions, primarily Parkinson's disease.18 Whereas autoantibodies against CLDN5 may indicate altered blood–brain barrier (BBB) functions,18 autoantibodies against intracellular adhesion molecule 1 (ICAM-1) and myelin basic protein (MBP) have been found in vascular and demyelinating diseases, respectively.19