TRIM72 and diabetes mellitus: In contrast, recombinant human MG53-S255A mutant (rhMG53-S255A), which has no adverse effect of glucose-raising, not only markedly ameliorates I/R-induced acute myocardial damage, but also effectively diminishes chronic maladaptive cardiac remodeling, including myocardial hypertrophy and fibrosis; regardless of the severity of diabetes.