Because AREG, F3, and G6PD play a crucial role in tumour growth, angiogenesis and metastasis, the interruption of AREG by cetuximab, panitumumab, irinotecan, or capecitabine and of F3 by simvastatin or G6PD by trimethoprim might represent strategies to specifically kill CSCs and overcome chemoresistance in this cancer (Figure 7G). The gene discussed is AREG; the disease is neoplasm.