Our clinical studies demonstrated that PTX3 signals were strongly detectable in fibroblastic foci of fibrotic lesions but expressed at low levels in the nonfibrotic regions of lung tissues from patients with fILD (Figure 1C), which is consistent with previous studies14, 27 and demonstrates a close connection between PTX3 levels and pulmonary fibrosis. The gene discussed is PTX3; the disease is pulmonary fibrosis.