BRAF and enteropathy-associated T-cell lymphoma: Hence, EATL is characterized by highly recurrent activating mutations in the JAK/STAT pathway, most commonly in JAK1 (at the p.c1097 hotspot) and STAT3, and rarely in JAK3, STAT5B, TYK2, or SOCS1. Other mutations occur in NFκB genes (TNFAIP3), genes involved in epigenetic regulation and gene expression (KMT2D, BCOR, DDX3X), mitogen-activated protein kinase (MAPK) pathway genes (KRAS, NRAS, BRAF), and TP53 [13, 40, 46, 52].