For example, the expression of FTO declines with ovarian aging, followed by increased m6A levels in old human granulosa cells.162 Furthermore, FTO is crucial for the progression of the G1 phase of the cell cycle by removing m6A from the cyclin D1 mRNAs and stabilizing them.163 The ALKBH5 level is increased during IVDD and NPC senescence, and it removes m6A from the DNMT3B mRNAs, which limits the expression of the transcription factor E4F1 by methylating CpG islands at its promoter region and accelerates NPC senescence.164. Here, FTO is linked to nasopharyngeal carcinoma.