METTL3 and osteoarthritis: Consistently, the expression of METTL3/14 and p21 is enhanced in oxidative-stress-induced senescence.17 Recently, ATG7 mRNAs with METTL3-dependent m6A were found to be destabilized by the reader YTH N6-methyladenosine RNA-binding protein 2 (YTHDF2), which promotes senescence instead of autophagy in fibroblast-like synoviocytes and leads to the progression of osteoarthritis.155 METTL14 also catalyzes the m6A modification affecting miRNAs associated with senescence.