APP and Alzheimer disease: For example, a tendency toward an overall increase in m6A methylation was observed in the cortex and hippocampus of the APP/PS1 transgenic mouse model for AD.169 Yet m6A in the 3ʹ UTR of many AD-associated transcripts in the 5XFAD mouse model of AD is downregulated, which is accompanied by an 8% increase and 4% decrease in FTO and METTL3, respectively, compared to wild-type mice, leading to higher Tau toxicity using the AD fly model.170