SIRT1 and Intervertebral disk degeneration: miR-34a-5p promotes celluar senescence by targeting Sirtuin-1 (SIRT1) in nucleus pulposus cells (NPCs) of patients with intervertebral disc degeneration (IVDD), one of the most prevalent degenerative diseases.156 More recently, the regulator WTAP, which functions to translocate METTL3/14 dimers to nuclear speckles,154 has also been demonstrated to be associated with IVDD.