HMGA1 and cancer: Functionally, HMGAs have been shown to be highly expressed in the embryo and downregulated during differentiation,[13] and their expression can be induced by mitogenic stimuli,[14] which links HMGAs to cell proliferative events including cancer.[15, 16] Furthermore, HMGA expression levels have now also been linked to DNA damage response and oncogene‐induced stress as well as senescence,[17, 18] and HMGA1 in particularly, was shown to be an essential component of senescence‐associated heterochromatic foci (SAHFs).[18]