It should also be noted that this conclusion is consistent with previous studies showing that the interaction between PRL and CNNM Mg2+ transporters is essential for PRL-induced cancer malignancy (Funato et al., 2014; Hardy et al., 2015; Gulerez et al., 2016; Kozlov et al., 2020; Hardie, 2007). This evidence concerns the gene PRL and cancer.