COL4A1 and Nephropathy: We determined the mRNA expression of 16 genes in Akita and Akita::Nrf2−/− mice, including the antioxidant and detoxification genes Nqo1, Hmox1 (encoding heme oxygenase 1), Gclc, Gclm and Gsr; the inflammation-related genes Il6, Il1b (encoding interleukin-1β, IL-1β), Ccl2 (MCP-1) and Adgre1 (encoding F4/80); the fibrosis-related genes Fn1 (fibronectin), Tgfb1 (TGF-β1), Col1a1, Col3a1 and Col4a1; and the kidney damage-related genes Havcr1 (KIM-1) and Lcn2 (NGAL).