To assess the consistency of the anti-leukaemia activity of CAR.CD123-NK cells independently from HLA-KIR haplotype mismatch, we used leukaemia blasts from 3 AML patients in long-term (6 days) coculture assays with CAR.CD123-NK cells derived from HDs and both patients and HDs were randomly identified, regardless of HLA mismatch. Here, IL3RA is linked to leukemia.