TNF and acute myeloid leukemia: Proinflammatory cytokines (namely, Granz B, IL-2, IFN-γ and TNF-α) evaluated after 24 h of coculture confirmed the higher activation of CAR.CD123-NK cells than NT-NK cells after incubation with primary AML CD123+ blasts (Fig. 3B; Granz B, IFN-γ, TNF-α p < 0.05).