HMGB1 and esophageal squamous cell carcinoma: The profile of exosomal HMGB1 was examined by ELISA, and the results revealed that the plasma exosomal HMGB1 levels of ESCC patients (1821 ± 386.6 pg/ml) were considerably higher than those of healthy controls (868.7 ± 119.3 pg/ml) (P = 0.0169) (Fig. 1D).