Among them, 72 patients received two PD-L1 expression tests, including 47 patients with two surgically-resected lesions (15 patients with second primary lung cancer and 32 patients with intrapulmonary metastasis), 12 patients with paired biopsy and surgical resection specimens, and 13 patients with two biopsies specimens for one lesion. This evidence concerns the gene CD274 and lung cancer.