Moreover, using an echocardiographic study, we found that baseline serum TSP2 levels were significantly associated with left ventricular remodeling and the subsequent deterioration of diastolic function in patients with type 2 diabetes but without CVD, highlighting the potential of circulating TSP2 level as a novel biomarker of HF in type 2 diabetes, regardless of the presence of CVD. This evidence concerns the gene THBS2 and hydrops fetalis.