Recently, plasma proteomic profiling had demonstrated that circulating TSP2 level was associated with incident HF in a population-based cohort, as well as the presence of acute HF among individuals attending the emergency department, independent of N-terminal pro-hormone BNP (NT-proBNP) and B-type natriuretic peptide (BNP), respectively [5, 6]. This evidence concerns the gene THBS2 and hydrops fetalis.