The addition of serum TSP2 levels into a clinical model, which consisted of age, sex, duration of diabetes, smoking status, BMI, hypertension, dyslipidemia, atrial fibrillation, CVD, HbA1c, CKD, albuminuria and serum hsCRP level at baseline, led to a significant improvement of c-statistics in predicting HHF from 0.79 (95%CI 0.78–0.81) to 0.81 (95%CI 0.79–0.83) (p = 0.003). This evidence concerns the gene THBS2 and chronic kidney disease.