(Supplemental Table S1) Moreover, serum TSP levels were significantly higher in men (p < 0.001), and among participants who had hypertension (p < 0.001), atrial fibrillation (p < 0.001), CVD (p = 0.004) and albuminuria (p < 0.001) than those who did not. This evidence concerns the gene THBS1 and hypertensive disorder.