It is noteworthy that other more severe iron overload models affecting hepcidin expression, such as the hepcidin-resistant model bearing the p.C326S mutation in Fpn, as well as the Hampsand HJV knockout model, do not show liver disease or endocrine problems despite pancreatic iron accumulation, probably due to greater resistance to oxidative stress injury of these mouse models (Altamura et al. 2020). This evidence concerns the gene HAMP and liver disorder.