These pathways included those involved in cancer (hsa05200), pancreatic cancer (hsa05212), estrogen signaling pathway (hsa04915), osteoclast differentiation (hsa04380), progesterone-mediated oocyte maturation (hsa04914), hepatitis B (hsa05161), Chagas disease (American trypanosomiasis, hsa05142), FoxO signaling pathway (hsa04068), protein-polysaccharide in cancer (hsa05205), toxoplasmosis (hsa05145), colorectal cancer (hsa05210), Ras signal pathway (hsa04014), and prolactin signal pathway (hsa04917). The gene discussed is PRL; the disease is American trypanosomiasis.