Combined with the prognostic information of laryngeal cancer patients in the GEO and TCGA databases, 9 genes related to the prognosis of laryngeal cancer, ACAA1, ACOT9, NCAPH2, NTHL1, CROT, ACSM3, SMS, EPHX2 and PON2, were screened out after merging the information. Here, EPHX2 is linked to laryngeal carcinoma.