8 hub lupus nephritis ferroptosis-related genes (LN-FRGs) which might be good biomarkers of ferroptosis in LN were identified in this study; they include KRAS, PIK3CA, EGFR, MAPK14, SRC, MAPK3, VEGFA, and ATM. These findings point to the immune response playing an important role in LN caused by ferroptosis via mutual regulation between hub LN-FRGs and immune-infiltrated cells. This evidence concerns the gene MAPK3 and lupus nephritis.