GBX2 and central nervous system cancer: Furthermore, NCBP3 is found in glioma tissues and cells to bind directly to small nucleolar RNA host gene 6 (SNHG6) and inhibit the transcription of gastrulation brain homeobox 2 (GBX2) in a manner that relies on polycomb repressive complex 2 (PRC2), thereby promoting malignant progression of gliomas46.